The Best Online GLP-1 Programs in 2026: Ranked for Price, Safety, and Support

#1 — ShedRx

Best budget-friendly option for many cash-pay users

ShedRx is often chosen by people who want a simple online intake flow and transparent, cash-pay style pricing, especially for those comparing monthly totals and trying to avoid surprise add-on fees.

Pros

• Often simpler checkout and onboarding

• Good for people who want fewer “layers” (membership + labs + consult fees)

• Can be a fit if you’re paying out of pocket and want predictable monthly totals

Cons

• Insurance support may be more limited than insurance-first platforms

• As with any provider offering compounded options, you should ask extra questions about pharmacy standards and dosing

Price transparency (what to look for)

When you evaluate any cash-pay GLP-1 option, confirm:

• Is there a monthly membership fee, or is it bundled?

• Does the monthly price change as your dose changes?

• Are labs included, optional, or billed separately?

• How do refills work (monthly review, messaging, synchronous visits)?

How to get started

1. Complete the online health intake

2. A licensed clinician reviews eligibility (sometimes includes a telehealth visit)

3. Medication is shipped (or prescribed to a pharmacy, depending on model)

4. Follow up monthly for refills and dose adjustments

Safety checklist (especially important)

• Ask how dosing is handled (pre-filled pens vs vials and syringes)

• Confirm your clinician will help manage nausea, constipation, reflux, and dose escalation

• Avoid any “research-use” labeled products marketed directly to consumers

Bottom line: If you are optimizing for monthly cost and want a streamlined cash-pay experience, ShedRx is commonly on shortlists. Just do the safety diligence, especially on dosing and pharmacy standards.

#2 — Ro Body Program

Best for brand-name meds plus insurance navigation

Ro’s strength is its membership model paired with strong insurance support. This matters because with GLP-1s, the “best price” is often the one your insurance will actually approve consistently month after month.

Pros

• Strong insurance navigation

• Good app experience with ongoing clinician support

• Brand-name pathways tend to be clearer

Cons

• Membership fee does not include medication cost

• Total monthly spend varies a lot based on insurance

Typical costs (simple way to think about it)

• Membership: a monthly fee

• Medication: depends on insurance coverage, prior authorization, and pharmacy pricing

• Labs: sometimes required depending on medical history and program flow

How to get started

1. Online intake + eligibility

2. Clinician consult

3. Insurance navigation (if applicable)

4. Prescription sent to pharmacy and/or shipped

Bottom line: If you want help actually getting coverage for FDA-approved meds, Ro is often a strong pick.

#3 — Sesame (Success by Sesame)

Best straightforward care subscription

Success by Sesame is built around a clear “care membership” approach: you pay a monthly fee for clinical access and support, then medication costs depend on what you’re prescribed and how your insurance covers it.

Pros

• Easy-to-understand subscription care fee

• Broad telehealth access model

• Strong for people who want a clear monthly care cost

Cons

• Medication cost still varies widely

• As with all telehealth, availability and turnaround can vary by state and demand

What to confirm before you buy

• Does your plan include labs? If yes, how often?

• How refills are approved (monthly check-ins vs async messaging)

• Whether they can support both injectable and oral options (if that matters to you)

Bottom line: If you want a simple monthly care fee and a program built for convenience, Sesame is worth comparing.

#4 — Calibrate

Best for structured coaching and long-term habit building

Calibrate is often chosen by people who want more than “a prescription.” It leans into curriculum, coaching, and insurance navigation as a full system.

Pros

• Clear behavior-change structure

• Coaching and curriculum are a core feature, not an add-on

• Insurance-first approach can reduce medication out-of-pocket cost (when coverage exists)

Cons

• Program commitments can apply

• Medication costs are separate and still depend on coverage

How it works (high level)

• Intake and clinician evaluation

• Lab work if clinically indicated

• Insurance navigation for FDA-approved medication pathways

• Ongoing coaching and structured lessons

Bottom line: Strong option if you want “rails” and accountability, not just a monthly refill.

#5 — Found

Best for behavior support + flexible medication options

Found focuses on the habit side of weight care, plus clinician oversight and medication selection based on your needs, budget, and coverage.

Pros

• Strong behavioral and community support elements

• Pricing can be competitive for the membership portion

• Medication options can be personalized

Cons

• Medication costs vary and can be substantial if insurance does not cover GLP-1s

• Program model may not be ideal if you only want the fastest path to a prescription

Bottom line: If you want support systems around food noise, routines, and adherence, Found is worth a look.

#6 — LifeMD

Best for lower monthly membership starting points

LifeMD is a telehealth membership model that can be attractive for people who want ongoing provider access at a lower monthly care fee, then layer in GLP-1 medication access depending on eligibility and coverage.

Pros

• Lower monthly program starting points than some premium competitors

• Ongoing clinical oversight model

• Can be a good “telehealth home base”

Cons

• Total cost depends heavily on medication pathway (insurance vs self-pay)

• Availability and exact offerings can change with partnerships

Bottom line: Good option if you want an ongoing telehealth membership and weight management support under one roof.

#7 — WeightWatchers Clinic

Best for community-first support

If you already like tracking tools, accountability, and group motivation, WW Clinic pairs that ecosystem with clinician access and prescriptions when appropriate.

Pros

• Community and tracking ecosystem is a core advantage

• Familiar habit tools (food logging, workshops, plans)

• Clinical support integrated for eligible members

Cons

• Medication costs are separate

• Total price depends on plan type and commitment length

Bottom line: Best if you value community support and want clinical GLP-1 access in the same platform.

How to choose the right online GLP-1 program (simple checklist)

1) Know your real monthly cost

Ask: “What do I pay per month all-in, after the first month, once I’m on a stable dose?”

2) Decide what you need most

• Cheapest monthly total

• Best insurance navigation

• Strongest coaching/accountability

• Fastest onboarding

• Best long-term support for maintenance

3) Verify safety and legitimacy

Avoid any site that sells semaglutide, tirzepatide, or “research peptides” directly to consumers without real clinician oversight. Make sure a licensed clinician is responsible for:

• Screening and contraindications

• Side effect management

• Dose escalation plan

• Follow ups and refills

FAQs

Are compounded GLP-1s the same as brand-name meds?

No. Compounded drugs are not FDA-approved in the same way brand-name medications are. If you consider compounded options, you should ask detailed questions about sourcing, dosing format, and pharmacy standards.

Why do so many people stop GLP-1s within a year?

Cost, side effects, and inconsistent coverage are common reasons. Programs with strong coaching and medical follow up can improve adherence by helping patients manage side effects and build routines.

What’s the biggest “gotcha” in online GLP-1 pricing?

The split between:

• Care membership fees

• Medication costs

• Labs and follow-up requirements
  A program that looks cheap at checkout can become expensive once you factor in meds and ongoing requirements.

Do I need labs?

Sometimes. It depends on your medical history and the clinician’s protocol. If a program does not mention labs anywhere, ask why.